Published Mar 13, 2018
Peter Rome


Objective: To discuss the management of a 12-year-old female patient with previously diagnosed chronic asthma.Clinical Features: The duration and severity of this case are noted.Intervention and Outcome: Positive resolution of the case, primarily through a regime of chiropractic spinal care and other natural measures suggests that a drugless or reduced drug exposure may be efficacious for some patients.Conclusion: I describe considerations and rationale for intervention based on chiropractic management. Given the amount of published empirical and more formal evidence related to the chiropractic management approach to asthma, further research is certainly justified. Such research may determine which types of asthmatic patients may provide positive outcomes. It may also determine which therapy or combination of therapies would be most efficacious for particular patients.
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Asthma, Vertebrae

1. Kim RS, Rhee YK. Overlap between asthma and COPD: where the two diseases converge. Allergy Asthma Immunol Res 2010;2(4):209-214
2. Holley AB. From asthma to COPD: what's air got to do with it? 2016
3. Causes of asthma. World Health Organisation.
4. Mayo Clinic Staff. Asthma causes.
5. Palmer DD. The science, art and philosophy of chiropractic. Portland Printing House Co. Portland, Oregon. 1910:424,818
6. Still AT. Osteopathy: Research and practice. Kirksville: Self Published. 1910:132-134
7. Lewit K Manipulative therapy in rehabilitation of the locomotor system. 3rd edn. Oxford. Butterworth Heinemann1999:283
8. Mohr H, Biedermann H. Manual therapy of the thoracic spine - Mechanical dyspnea syndrome. In: Biedermann H: Manual therapy in children. Edinburgh. Churchill Livingstone;2004:194-196
9. Maigne R. Functional disturbances. In: Orthopaedic medicine. A new approach to vertebral manipulations. Springfield. Charles C Thomas. 1972:164
10. Bronfort G. Asthma and chiropractic. Europ J Chiropr 1996;44:1-7
11. Gleberzon BJ, Arts J, Mei A, McMannus EL The use of spinal manipulative therapy for pediatric health conditions: a systematic review of the literature. J Can Chiropr Assoc 2012;56(2)128-142
12. Hondras MA, Linde K, Jones AP. Manual therapy for asthma. Cochrane Database of Systematic Reviews DOI: 10.1002/14651858.CD001002.pub2. April 2005
13. Index to Chiropractic Literature
14. Osteopathic Medical Digital Repository.
15. Pepino VC, Ribeiro JD, Ribeiro MA, de Noronha M, Mezzacappa MA, Schivinski CI. Manual therapy for childhood respiratory disease: a systematic review. J Manipulative Physiol Ther 2013;36(1):57-65
16. Crosta P. Asthma history through the ages 2013
17. Allergy & Allergy Medical Group & Research Center. Extracted April 5,2017
18. Monell GC. Rheumatism, acute and chronic: A prize essay. New York: HG Langley;1845:20. As cited by Haldeman S. Principles and practice of chiropractic. 2nd edn. Norwalk: Appleton & Lange;1992:10
19. Pottenger FM. Asthma considered in its relationship to the vegetative nervous system. Am J Med Sci 1918 417-242
20. Pottenger FM. Important reflex relationships between the lung and other viscera. J. of Thor. Surg 1931;Oct:75-90
21. Murphy W, Wilson PT. A study of the value of osteopathic adjustment of the fourth and fifth thoracic vertebrae in a series of twenty cases of asthmatic bronchitis. Boston Med Surg 1925;192:440-442
22. Marlin T. Some common complaints amenable to spinal treatment. BMJ 1931;Oct 24:746
23. Speransky AD. Experimental and clinical lobar pneumonia. Am. Rev. of Soviet Med 1944;2:22-27
24. Zhigalina LI. The role of non-specific stimulation of the nervous system in certain immunological reactions. In: Gordienko AN. (Ed). Control of immunogenesis by the nervous system. Rostov-On-Don State Medical Institute, 1958:110-124
25. Hahn WW. Autonomic responses of asthmatic children. Psychosomatic Med 1966;28:323-332
26. Miklich DR. Salivary flow as measures of parasympathetic nervous system involvement in children's asthma. Psychosomatic Med 1974;36(3):206-214
27. Steyn E, Mohamed Z, Husselman C. Non-invasive vagus nerve stimulation for the treatment of acute asthma exacerbations - results from an initial case series. Int J Emerg Med 2013;6:7 doi:10.1186/1865-1380-6-7
28. Simonsson BG, Jacobs FM, Nadel JA. Role of the autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airways disease. J Clin Invest 1967;46(11):1812-1819
29. Kuselman AI, Deryabina EV. Application of quantum therapy in complex treatment of bronchial asthma in children. Photodiagnosis Photodynamic Ther 2012;9 (Suppl 1):S28. (Abstract)
30. Causes of asthma.
31. Fact sheet. What causes asthma? National Asthma Council Australia.
32. Dunn RM, Lehman E, Chinchilli VM, et al. Impact of age and sex on response to asthma therapy. Am J Resp Crit Care Med 2015;192(5):551-558. DOI:
33. Romieu I, Castro-Giner F, Kunzli N, Sunyer J. Air pollution, oxidative stress and dietary supplementation: a review. Eur Resp J 2008;31:179-197
34. Kanabar D, Dale S, Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 2007;29(12):2716-2723
35. Dimich-Ward H, Chow Y, Chung J, Trask C. Contact with livestock - a protective effect against allergies and asthma? Clin Exp Allergy 2006;36(9):1122-1129
36. Hugg TT, Jaakkola MS, Ruotsalainen R, Pushkarev V, Jaakkola JJ. Exposure to animals and the risk of allergic asthma: a population-based cross-sectional study in Finnish and Russian children. Environ Health 2008;7:28. doi: 10.1186/1476-069X-7-28
37. Fall T, Lundholm C, Ortqvist AK, et al. Early exposure to dogs and farm animals and the risk of childhood asthma. JAMA Pediatr 2015;169(11):e153219. doi:10:1001/jamapediatrics.2015.3219
38. van Dijk CE, Garcia-Aymerich J, Carsin AE, et al. Risk of exacerbations in COPD and asthma patients living in the neighbourhood of livestock farms: Observational study using longitudinal data. Int J Hyg Environ Health 2016 May;219(3):278-87. doi: 10.1016/j.ijheh.2016.01.00
39. Asmus MJ, Barros MD, Liang J, Chesrown SE, Hendeles L. Pulmonary function response to EDTA, an additive in nebulized bronchodilators. J Allergy Clin Immunol 2001;107(1):68-72
40. Su Y, Rothers J, Stern DA, Halonen M, Wright AL. Relation of early antibiotic use to childhood asthma: confounding by indication? Clin Exp Allergy 2010;40(8):1222-1229
41. Mangione-Smith R, Krogstad P. Antibiotic prescription with asthma medications: why is it so common, Pediatrics 2011;127:6:1174-1176
42. Brusselle GG, van Braeckel EV. AZALEA trial highlights antibiotic overuse in acute asthma attacks. JAMA Intern Med 2016;176(11):1637-1638 doi:10.1001/jamainternmed.2016.6046
43. Marra F, Lynd L, Coombes M, et al. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and meta-analysis. Chest 2006;129(3):610-618
44. Potera C. Asthma: a gut reaction to antibiotics. Environ Health Perspec 2005;113(6)A372.
45. Chung WS, Lin CL, Chen YF, Ho FM, Hsu WH, Kao CH. Increased stroke risk among asthmatic patients. Eur J Clin Invest 2014 Nov;44(11):1025-33. doi: 10.1111/eci.12336
46. Arrieta MC, Finlay B. The intestinal microbiota and allergic asthma. J Infect 2014;69(Suppl 1):S53-5. doi: 10.1016/j.jinf.2014.07.015
47. Rothers J, Stern DA, Spangenberg A, et al. Influence of early day-care exposure on total IgE levels through age 3. J Allergy Clin Immunol 2007;120(5):1201-1207
48. Sun Y, Sundell J. Early daycare attendance increases the risk for respiratory infections and asthma of children. J Asthma 2011 Oct;48(8):790-6. doi: 10.3109/02770903.2011.604884
49. Luijk MPCM, Sonnenschein-van der Voort AMM, Mileve-Seitz VR, et al. Is parent-child bed-sharing a risk for wheezing and asthma in early childhood. Europ Resp J 2015;45(3):661-669. DOI: 10.1183/09031936.00041714
50. Lin TC, Lee TC, Lai TJ, et al. Association of asthma and bipolar disorder: a nationwide population-0based study in Taiwan. J Affect Disord 2014 Oct;168:30-6. doi: 10.1016/j.jad.2014.06.033
51. Worrill NA. Asthma: a descriptive case study. Br J Chiro 1998(2:1):4-5
52. Chen W, Fitsgerald JM, Rouiseau R, et al. Complementary and alternative asthma treatments and their association with asthma control: a population-based study. BMJ Open 2013;3:e003360 doi:10.1136/bmjopen-2013-003360
53. Chung WS, Shen TC, Lin CL, Chu YH, Hsu WH, Kao CH. Adult asthmatics increase the risk of acute coronary syndrome: a nationwide population-based cohort study. Eur J Intern Med 2014; 25(10):941-5. doi: 10.1016/j.ejim.2014.10.023
54. Barnes PJ. Efficacy of inhaled corticosteroids in asthma. J Allergy Clin Immunol 1998;102(4 Pt 1):531-538
55. Sevelsted A, Stokholm J, Bisgaard H. Risk of Asthma from Caesarean Delivery Depends on Membrane Rupture. J Pediatr 2016 Apr;171:38-42.e1-4. doi: 10.1016/j.jpeds.2015.12.066
56. Xu B, Pekkansen J, Hartikainen A-L, Järvelin M-R. Caesarean section and risk of asthma and allergy in adulthood. J Allergy Clin Immunol 2001;107(4):732-733
57. Oren E. Rothers J, Stern DA, Morgan WJ, Halonen M, Wright AL. Cough during infancy and subsequent childhood asthma. Clin Exp Allergy 2015;45(9):1439-1446
58. Li Z, Rava M, Bedard A, et al. Cured meat intake is associated with worsening asthma symptoms. Thorax 2016; pii: thoraxjnl-2016-208375. doi: 10.1136/thoraxjnl-2016-208375
59. Weinmayr G, Gehring U, Genuneit J et al. Dampness and moulds in relation respiratory and allergic symptoms in children: results from phase two of the international study of asthma and allergies in childhood (ISAAC Phase Two) Clin Exp Allergy 2013;43(7):762-774
60. Bush A, Fleming L. Is asthma overdiagnosed? Arch Dis Child 2O15
61. Woodhead M. Trivialising asthma leading to child deaths, warn doctors. Australian Doctor 2016;April 6.
62. Aaron SD, Vandemheen KL, Fitzgerald JM. Re-evaluation of diagnosis in adults with physician=diagnosed asthma. JAMA 2017;317(3):269-279.doi:10.1001/JAMA.2016.19627
63. Kim JL. Eifman L, Mi Y, Johansson M, Smegje G, Norback D. Current asthma and respiratory symptoms among pupils in relation to dietary factors and allergens in the school environment. Indoor Air 2005;15:170-182
64. Trask S. Diet positive management through diet. University of Newcastle's Priority Research Centre for Healthy Lungs 'Radical' asthma approach could change treatment. March 27, 2017
65. Toelle B, Garden FL, Ng KKW, et al. Outcomes of the childhood asthma prevention study at 11.5 years. J Allergy Clin Immunol 2012
66. Nafstad P, Nystad P, Magnus P, Jaakkola JJ, Asthma and allergic rhinitis at 4 years of age to fish consumption in infancy. J Asthma 2003;40:343-348
67. Ribó P, Pacheco A, Arrieta P, Teruel C, Cobeta I. Gastroesophageal reflex as a cause of chronic cough, severe asthma, and migratory pulmonary infiltrates. Respirol Case Rep 2014;2(1):1-3
68. Bereznicki BJ, Beggs S, Duff C, Beresnicki L. Adherence to management guidelines for childhood asthma in Australia. Aust Family Physic 2015;44(12):933-938
69. Chen SJ, Huang KH, Tsai WC, Lin CL, Cheng YD, Wei CC. Asthma Status is an Independent Risk Factor for Herpes Zoster in Children: A Population-Based Cohort Study. Ann Med 2017 Mar 23:1-24. doi: 10.1080/07853890.2017.1309060
70. Ahluwalia SK, Peng RD, Breysse PN, et al. Mouse allergen is the major allergen of public health relevance in Baltimore City. J Allergy Clin Immunol 2013;132(4):830-835.e2
71. Bacharier LB. Reducing exposure to mouse allergen among children and adolescents with asthma is achievable, but is it enough? JAMA 2017 Mar 14;317(10):1023-1025. doi: 10.1001/jama.2016.21181
72. Marsui EC, Perzanowski M, Peng RD, et al. Effect of an integrated pest management intervention on asthma symptoms among mouse-sensitized children and adolescents with asthma. JAMA 2017;317(10):1027-1036. DOI: 10.1001/jama.2016.21048
73. Blum CL. Roll of chiropractic and sacro-occipital technique in asthma treatment. J Chiropr Med 2002;1(1):16-22
74. Kartha GK, Li I, Comhair S, Erzurum SC, Monga M. Co-occurrence of asthma and nephrolithiasis in children. PLoS One
75. Jason E, Lang MD. Obesity, nutrition, and asthma in children. Pediatr Allergy Immunol Pulmonology 2012;25(2):64-75
76. Chinn S. Obesity and asthma. Paediatr Resp Rev 2006;7(3):223-228
77. Miyata J, Arita M. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Japanese Society Allergology 2015;64(1):27-34
78. Eyers SJ. The effect of regular paracetamol on bronchial responsiveness and asthma control in mild to moderate asthma. Thesis. University of Otago, Wellington, NZ. 2012.
79. Simpson AB, Yousef E, Hossain J. Association between peanut allergy and asthma morbidity. J Pediatr 2010;156(5):777-781
80. McConnell R, Berhane K, Yao L, et al. Traffic, susceptibility and childhood asthma. Environ Health Perspec 2006;114(5);766-772
81. Kelly W, Massoumi A, Lazarus A. Asthma in pregnancy: physiology, diagnosis, and management. Postgrad Med 2015;127(4):349-358
82. Lagerløv P, Loed M, Andrew M, Hjortdahl P. Improving doctors' prescribing behaviour through reflection on guidelines and prescription feedback: a randomised controlled trial. Qual Health Care 2000;9(3):159-165
83. Su YL, Chou CL, Rau KM, Lee CT. Asthma and risk of prostate cancer: a population-based case-cohort study in Taiwan. Med (Baltimore) 2015 Sep;94(36):e1371. doi: 10.1097/MD.0000000000001371
84. Luyster FS, Teodorescu M, Bleeker E, et al. Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath 2012;16(4):1129-1137
85. Bird Y, Staines-Orozco H. Pulmonary effects of active smoking and secondhand smoke exposure among adolescent students in Janez, Mexico. Int J Obstruct Pulmon Dis 2016;11:1459-1467
86. Moraros J, Bird Y, Chen S, et al. The impact of the 2002 Delaware smoking ordinance on heart attack and asthma. Int J Environ Res Public Health 2010;12: 4169-4178. doi: 10.3390/ijerph7124169
87. Cisneros R, Gonzales M, Brown P, Schweizer D. Soda consumption and hospital admissions among Californian adults with asthma. J Asthma 2017;54(4):371-375
88. Zhang L. Prietsch AOM, Ducharme FM. Inhaled cortisone in children with persistent asthma: effects on bone growth. Cochrane Database of Systematic Rev 2014; DOI: 10.1002/14651858.CD009471
89. Wong CA, Walsh LJ, Smith CJP, et al. Inhaled corticosteroid use and bone-mineral density in patients with asthma. The Lancet 2000;355(9213):1399-1403
90. Sosa M, Saavedra P, Valero C, et al. Inhaled steroids do not decrease bone mineral density but increase risk of fractures: data from GIUMO study group. J Clin Densitometry 2006;9(2):154-158. DOI: 10.1016/j.jocd.2005.11.005
91. Rod NH, Kristensen TS, Lange P, Prescott E, Diderichsen F. Perceived stress and risk of adult-onset asthma and other atopic disorders: a longitudinal cohort study. Allergy 2012;67:1408-1414
92. Carlson S, Borrell LN, Eng C, et al. Self-reported racial/ethnic discrimination and bronchodilator response in African youth with asthma. PLoS
93. Bédard A, Northstone K, Henderson AJ, Shaheen SO. Maternal intake of sugar during pregnancy and childhood: respiratory and atopic outcomes. Eur Resp J 2017;50(1). pii: 1700073. doi: 10.1183/13993003.00073-2017
94. Laino C. Sugar intake linked to kids' asthma. Web MD.
95. Bernard A, Nickmilder M, Voisin C. Outdoor swimming pools and the risks of asthma and allergies during adolescent. Eur Rep J 2008;32(4):979-988
96. D'Amato G, Liccardi G, Frenguelli G. Thunderstorm-asthma and pollen allergy. Allergy 2007, 62(1):11-16
97. Bellomo R, Gigliotti P, Treloar A, et al. Two consecutive thunderstorm associated epidemics of asthma in the city of Melbourne. The possible role of rye grass pollen. Med J Aust 1992;156(12):834-837
98. Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Free Radic Res 2008;42(1):94-102
99. Zacharisen MC, Elms NP, Kurup VP. Severe tomato allergy (Lycopersicon esculentum). Allergy Asthma Proc 2002;23(2):149-152
100. Thomas PS. Tumour necrosis factor-apha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 2001;79(2):132-140
101. Steyn E, Mohamed Z, Husselman C. Non-invasive vagus nerve stimulation for the treatment of acute asthma exacerbations - results from an initial case series. Int J Emerg Med 2013; 6:7 doi:10.1186/1865-1380-6-7
102. Martineau AR, Cates CJ, Urashima M, et al. Vitamin D to prevent asthma attacks. 2016; Cochrane Database Syst Rev 2016 Sep 5;9:CD011511
103. Stone CA. Am Acad Allergy,Asthma & Immunology 2017 Medscape
Maternal Levels of Vitamin E Isoform Linked to Child Asthma
American Academy of Allergy, Asthma, & Immunology (AAAAI) 2017 Annual Meeting. Abstract 263. March 4, 2017.
104. Hesselmar B, Hicke-Roberts A, Wannergren G. Allergy in children in hand verses machine dishwashing. Pediatrics 2015;135(3):e1-e8
105. Finlay B, Arrieta M-C. Univ British Columbia Yeast found in babies guts increases risk of asthma. 2017. Feb 17.
106. Asthma management. National Asthma Council Australia. Aug 2015
107. Gibbons GH. How is asthma treated and controlled? National Heart, Lung, and Blood Institute. October 28, 2013
108. Engel R. The effect of combining spinal manipulation with exercise on respiratory function. (Platform presentation, The Association of Chiropractic Colleges. 13th Annual Conference. Washington, March 14-16, 2006
109. Hawk C, Khorsan R, Lisi AJ, Ferrance RJ. Evans MW. Chiropractic care for non-musculoskeletal conditions: a systematic review with implications for whole system research. J Altern Complement Med 2007;13(5):491-512
110. Gatterman MI. Chiropractic management of spine related disorders. Baltimore: Williams & Wilkins. 1990;390-392
111. Dougherty PE, Engel RM, Vemulpad S, Burke J. Spinal manipulative therapy for elderly patients with chronic obstructive pulmonary disease. A case series. J Manipulative Physiol Ther 2011;34(6):413-417
112. Engel RM, Venulpad SR, Beath K. Short term effects of a course of manual therapy in people with moderate chronic obstructive pulmonary disease: a preliminary clinical trial. J Manipulative Physiol Ther 2013;36(8):4909-496
113. McElvey SE, Bull P. The chiropractic cop-management of asthma: a clinical research approach. J Chiropr Edu 2010;24(1):135
114. Redwood D, Cleveland CS. Fundamentals of chiropractic. St Louis. Mosby.2003;355,360,536-539
115. Eriksen K. Upper cervical subluxation complex. Philadelphia. Lippincott: Williams & Wilkins; 2004:405-406
116. Guiney PA, Chou R, Vianna A, Lovenheim J. Effects of osteopathic manipulative treatment on pediatric patients with asthma: a randomised controlled trial. J Am Ostop Assoc 2005;105(1):7-12. doi:10.7556/jaoa.2005.105.1.7
117. Brockenhauer SE, Julliard KN, Lo KS, Huang E. Sheth AM. Quantifiable effects ofo osteopathic manipulative techniques on patients with chronic asthma. J Am Osteop Assoc 2002;102:371-375
118. King HH, Jänig W, Patterson MM. The science and clinical application of manual therapy. Edinburgh: Churchill Livingstone;2011:94,223-225
119. Bruuns MLJ, van der Giessen LJ, Moed H. The effectiveness of physiotherapy in patients with asthma: a systematic review of the literature. Resp Med 2013;107(4):483-494
120. Bergsmann O. [The mechanical dyspnea syndrome: breath movement and thoracic disturbance.] Das mechanisch-dyspnoische Syndrom - thorakle Störung der Atembewegung. Manuelle Medizen 1974;12:79. (Cited in: Lewit K. Manipulative therapy in rehabilitation of the locomotor system. 3rd edn. Butterworth Heinemann, Oxford. 1999:283.)
121. Köberle G. [Examples of joint disturbance with chronic-obstructive airway disease.] Arthrologische Störungsmuster bei chronisch-obstruktiven Atemwegserkrankungen. In: Functional pathology of the motor system, Rehabilitacácia Suppl 10-11, p 96. Eds: Lewit K, Gutmann G. Bratislava: Obzor. 1975. (Cited in: Lewit K. Manipulative therapy in rehabilitation of the locomotor system. 3rd edn. Butterworth Heinemann, Oxford. 1999:283.)
122. Sachse T, Sachse J. [Muscle findings with chronically obstructive airway diseases.] Muskelbefunde bei chronisch obstruktiven Atemwegserkrankungen. In: Functional pathology of the motor system, Rehabilitacácia Suppl 10-11, p 98 Eds Lewit K, Gutmann G. Bratislava: Obzor. 1975. (Cited in: Lewit K. Manipulative therapy in rehabilitation of the locomotor system. 3rd edn. Butterworth Heinemann, Oxford. 1999:283.)
123. Bronfort G, Haas M, Moher D, et al. Review conclusions by Ernst and Canter regarding spinal manipulation refuted. Chiropr Man Ther 2006;14:14. doi:10.1186/1746-1340-14-14
124. Bogen J. Theory and observation in science. Stanford Encyclopedia of Philosophy. 2017 (Extracted May 8, 2017.)
125. Jindal SK, Kaur SJ. Relative bronchodilatory responsiveness attributable to sympathetic and parasympathetic activity in bronchial asthma. Respiration 1989;56:15-21
126. Kozlova VI. [The influence of skeletal muscle proprioception impulses on the functional state of the respiratory center.] Fiziol Zh SSSR Im I M Sechenova. 1970;56(5):759-763. (Russian) (Pubmed extract only)
127. Miner JR, Lewis LM, Mosnaim GS et al. Feasibility of percutaneous vagus nerve stimulation for the treatment of acute asthma exacerbations. Acad Emerg Med 2012.19(4):421-429
128. Steyn E, Mohamed Z, Husselman. Non-invasive vagus nerve stimulation for the treatment of acute asthma exacerbations - results from an initial case series. Internl J Emerg Med 2013, 6:7 doi:10.1186/1865-1380-6-7
129. Field T, Henteleff T, Hernandez-Reif M, Martinez E, Mavunda K, Kuhn C, Schanberg S. Children with asthma have improved pulmonary functions after massage therapy. Journal of Pediatrics 1998; 132(5): 854-858
130. Cox SF, Tornatore RA, Marquina N. The effect of adjusting on tissue oxygenation and chest expansion. J Chiro Educ 2000;14(1):30-31
131. Devi TP, Kanan W, Singh TS, Asoka W, Benjamin L. A study of the sympathetic nervous system in bronchial asthma. J Med Society 2012;26(3):159-162
132. Reed CE. Abnormal autonomic mechanisms in asthma. J Allergy Clin Immunol 1974;53:34-41
133. Shar PL, Lakhotia M, Mehta S, Jain SK, Gupta GL> Clinical dysautonomia in patients with bronchial asthma. Study with seven autonomic tests. Chest 1990;98:1408-1413
134. Kumar M, Verma NS, Tiwari S, Pandey US. Sympathetic hyperactivity in patients of bronchial asthma. Indian J Physiol Pharmacol 2005;49:89-94
135. Allen TW, Pence TK. The use of the thoracic pump in treatment of lower respiratory tract disease. J Am Osteop Assoc 1967;67(12):86-89
136. Miller CE. Osteopathic principles and thoracic pump therapeutics proved by scientific research. J Am Osteop Assoc 1926;26(7):910-914
137. Chauhan AJ, et al. Regular balloon inflation for patients with chronic bronchitis: a randomised controlled study. BMJ 1992;304:1668-9
138. Asthma Foundation Victoria Fact sheet. Asthma and Complementary therapies.
139. Schneider A, Gindner L, Tileman L, et al. Diagnostic accuracy of spirometry in primary care. BMC Pulm Med 2009;9:31
140. Jongeward BV, Chiropractic manipulation for childhood asthma. N Engl J Med 1999;340:391-392
141. Seaman DR, Winterstein JF. Dysafferentation: A novel term to describe the neuropathophysiological effects of joint complex dysfunction. A look at likely mechanisms of symptom generation. J Manipulative Physiol Ther 1999;22(1):45-48
142. Pickar JG. Neurophysiological effects of spinal manipulation. Spine J 2002;2(5):357-371
143. Sato A, Sato Y, Schmidt RF. The impact of somatosensory input on autonomic functions.. In: Reviews of Physiology Biochemistry and Pharmacology. Blaustein MP et al Eds. Springer-Verlag, Berlin. 1997;v130.253-256
144. Bolton PS, Budgell B. Visceral responses to spinal manipulation. J Electromyogr Kinesiol 2012;22(5):777-784
145. Henderson CN. The basis for spinal manipulation: chiropractic perspective of indications and theory. J Electromyogr Kinesiol. 2012;22(4):632-642. doi: 10.1016/j.jelekin.2012.03.008. Epub 2012 Apr 17
146. Haavik Taylor H, Holt K, Murphy B. Exploring the neuromodulatory effects of the vertebral subluxation and chiropractic care. Chiropr J Aust 2010;40(1):37-44
147. Cramer G, Budgell B, Henderson C, Khalsa P, Pickar J. Basic science research related to chiropractic spinal adjusting: the state of the art and recommendations revisited. J Manipulative Physiol Ther 2006;29(9):726-761
148. Hayek R. Chiropractic management of asthma: anatomy, evidence and best practice. World Federation of Chiropractic 8th Biennial Congress. Sydney, June 16-18, 2005:95
149. Alcantara J, Alcantara JD, Alcantara J. The chiropractic care of patients with asthma; a systematic review of the literature to inform clinical practice. Clin Chiropr 2012;15(1):23-30
150. Kaminskyj A, Frazier M, Johnstone K, Gleberzon BJ. Chiropractic care for patients with asthma: a systematic review of the literature. J Canad Chiropr Assoc 2010;54(1):24-32
151. Bronfort G, Evans PL, Kubic P, Filkin P. Chronic paediatric asthma and chiropractic manipulation. A prospective clinical series and randomised clinical pilot study. J Manipulative Physiol Ther 2001;24(6):369-377
152. Nielsen NH, Bronfort G, Bendix T, Madsen F, Weeke B. Chronic asthma and chiropractic spinal manipulation: a randomised clinical trial;. Clin Exp Allergy 1995;25(1):80-88
153. Hviid A. A comparison of the effects of chiropractic treatment on respiratory function in patinets with respiratory distress symptoms and patients without. Bull Europ Chiro Union 1978;26:17-34
154. Lines D. A wholistic approach to the treatment of bronchial asthma in a chiropractic practice. Chiro J Aust 1993;23(1):4-8
155. Lines D, McMillam A, Spehr G. Effects of soft tissue technique and Chapman's neurolymphatic reflex stimulation on respiratory function. J Australian Chiropractor's Assn March 1990;20(1):17-22
156. Rocha T, Souza H, Brandao DC, et al. The manual diaphragm release technique improves diaphragmatic mobility, inspiratory capacity and exercise capacity in people with chronic obstructive pulmonary disease: a randomised trial. J Physiotherapy 2015;61(4):182-189
157. McCulloch P. A simple mode illustrating the balancing forces of lung and chest wall recoil. Advances Physiol Educ 2004;28(3):125-127 DOI: 10.1152/advan.00011.2004
158. Bottrell J. Why does asthma cause chest pain.
159. Sato A. Neural mechanisms of autonomic responses elicited by somatic sensory stimulation. Neurosci Behav Physiol 1997 Sep-Oct;27(5):610-21
160. Kimura A, Sato A. Somatic regulation of autonomic functions in anesthetized animals - neural mechanisms of physical therapy including acupuncture. Jpn J Vet Res 1997;45(3):137-145
161. Sato A. Neural mechanisms of autonomic responses elicited by somatic stimulation. Neurosci Behav Physiol 1997;27(5):610-621
162. Sato A. Somatovisceral reflexes. J Manipulative Physiol Ther 1995;18(9):597-602.
163. Sato A. The reflex effects of spinal somatic nerve stimulation on visceral function. J Manipulative Physiol Ther 1992;15(1):57-61
164. Nelson KE, Glonek T. Somatic dysfunction in osteopathic family medicine. Philadelphia. Lippincott Williams & Wilkins. 2006
165. Leach RA. The chiropractic theories: Principles and clinical application. 3rd edn. Baltimore. Williams & Wilkins. 1994:108-115, 180-183
166. Uchida S, Budgell B. Somato-autonomic reflex. In: Binder MD, Hirokawa N, Windhorst U. Encyclopaedia of Neuroscience. 2009. 3767-3779. 10.1007/978-3-540-29678-2_5500
167. Physiology II. Cardiovascular physiology. Control of ventilation. (Citing Guyton 9th edn, Ganong, 19th edition) (Extracted 22.7.2017)
168. Autonomics of the thorax. 2002
169. Goyal M1, Jaseja H, Verma N. Increased parasympathetic tone as the underlying cause of asthma: a hypothesis. Med Hypotheses 2010 Apr;74(4):661-4. doi: 10.1016/j.mehy.2009.11.011. Epub 2009 Dec 30
170. Muscles of respiration.
171. van der Velden M, Hulsmann AR. Autonomic innervation of human airways: structure, function, and pathophysiology in asthma. Neuroimmunomodulation 1999;6(3):145-159
172. Jarth T. Asthma, asthma medication and autonomic nervous system dysfunction. Clin Physiol 2001;21(2):260-269
173. Emin O, Esra G, Aysegul D, et al. Autonomic nervous system dysfunction and their relationship with disease severity in children with atopic asthma. Respir Physiol Neurolbiol 2012;183(3):206-210
174. Mukhopadhyay J, Bates R, Manney S, Ayres JG. Changes in vagal tone with posture in asthma are related to changes in ventilator pattern. Resp Med 2007;101(5):1001-1006
175. Ichinose M. [Airway autonomic nervous system dysfunction and asthma].Nihon Kokyuki Gakkai Zasshi 1999 Jan;37(1):3-9. (Abstract only) [Article in Japanese]
176. Engel-Yeger B, Almog M, Kessel A. The sensory profile of children with asthma. ACTA Paediatrica 2014; 103(11):e490-494. DOI: 10.1111/apa.12746
177. Gordienko AN. (Ed) Control of immunogenesis by the nervous system. (Translation) Washington DC, National Science Foundation Dept HEW,1960. [Original - Rostov-On-Don Medical Institute, 1958. Translated by The Israel Program for Scientific Translation.]
178. Barnes PJ. Efficacy of inhaled corticosteroids in asthma. J Allergy Clin Immunol 1998;102(4 Pt 1):531-538
179. Brennan PC, Kokjohn K, Kaltinger CJ. Enhanced phagocytic cell respiratory burst induced by spinal manipulation: potential role of substance P. J Manipulative Physiol Ther 1991;14:399-408.
180. . Hayek R. Effect of chiropractic treatments on the endocrine and immune system in asthmatic patients. Proceedings of the 2002 International Conference on Spinal Manipulation, Toronto Ontario, Canada, Oct 2002:57-58
181. Hayek R, Ali S, Holland R, et al. Somatovisceral effects of chiropractic treatment on the hypothalamo-adrenal axis and immunity of the respiratory system in asthmatics [Conference abstract] Eur J Chiropr 2002;49(1):87
182. Sears MR, Burrows B, Flannery EM, Harbison GP, Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991;325(15):1067
183. Waddell SC, Davidson JS, Befus AD, Mathison RD. Role for the cervical sympathetic trunk in regulating anaphylactic and endotoxic shock. J Manipulative Physiol Ther 1992;15(1):10-15
184. Alcantara J, van Roo L, Oman RE. Chiropractic care of a pediatric patient with asthma, allergies, chronic colds and vertebral subluxations. J Pediatr Matern Fam Health 2009;3:27-29
185. Whittle-David H, Czegus K. Chiropractic care of a pediatric patient with asthma: A case report. J Pediatr Matern Fam Health 2011;3:77-81
188. Young RL, Page AJ, Cooper NJ, Frisby CL, Blackshaw LA. Sensory and motor innervation of the crural diaphragm by the vagus nerve. Gastroenterol 2010;138(3):1091-1101.e1-5. doi: 10.1053/j.gastro.2009.08.053. Epub 2009 Sep 2
189. Crural diaphragm contribution to EGJ and neural control. Morgan & Claypool Life Sciences. 2011
190. O'Rahilly, Müller, Carpenter & Swenson. Basic Human Anatomy.
191. Janssens L. Brumagne S, McConnell AK, Hermans G, Troosters T, Gayan-Ramirez G. Greater diaphragm fatigability in individuals with recurrent low back pain. Respir Physiol Neurobiol 2013;188(2):119-123
192. Beeckmans N, Vermeersch A, Lysens R. et al. The presence of respiratory disorders in individuals with low back pain: a systematic review. Man Ther 2016;26:77-86
193. Davies NJ. Chiropractic paediatrics. A clinical handbook. Edinburgh. Churchill livingstone;2000;147-152
194. Bockenhauer SE, Julliard KN, Lo KS, Huang E, Sheth AM. Quantifiable effects of osteopathic manipulative techniques on patients with chronic asthma. J Am Osteopath Assoc 2002 Jul;102(7):371-5
195. Gorini M, Iandelli I, Misuri G, et al. Chest wall hyperinflation during acute bronchoconstriction in asthma. Am J Resp Crit Care Med 1999;160(3):808-816
196. Janse J, Houser RH, Wells BF. Chiropractic principles and technic. Chicago National College of Chiropractic;1947:186-189,627-629
197. Hill AR. Respiratory muscle function in asthma. J Assoc Acad Minor Phys 1991;2(3):100-108. (Abstr)
198. Beeckmans N, Vermeersch A, Lysens R. et al. The presence of respiratory disorders in individuals with low back pain: a systematic review. Man Ther 2016;26:77-86
199. Martin JG, Shore SA, Engel LA. Mechanical load and inspiratory muscle action during induced asthma. Am Rev Resp Dis 1983;128(3):455-460
200. Dunne C. Thoracic pump. Feb 24, 2017
201. Noll DR, Johnson JC, Baer RW, Snider EJ. The immediate effect of individual manipulation techniques on pulmonary function measures in persons with chronic obstructive pulmonary disease. Osteop Med Prim Care 2009;3:9. doi: 10.1186/1750-4732-3-9
202. Taylor BJ, Romer LM. Effect of expiratory resistive loading on inspiratory and expiratory muscle fatigue. Respir Physiol Neurobiol 2009;166(3):164-174
203. Freitas DA, Holloway E, Bruno SS, et al. Breathing exercises for asthma. Cochrane Database of Systemic Review 1 Oct 2013
204. Macâdo TMF, Freitas DA, Chaves GSS, Holloway E, Mendonça KMPP. Breathing exercises for children with asthma.
205. Bott J, Blumenthal S, Buxton M, et al. Guidelines for the physiotherapy management of the adult, medical, spontaneously breathing patient. Asthma and disordered breathing. - Exercises.
206. Stamford B. Exercise and chronic airway obstruction. Physician Sportsmed 1991;19(3):189-190
207. Carson KV, Chandratilleke MG, Picot J, Brinn MP, Esterman AJ, Smith BJ. Physical training for asthma. Cochrane Database Syst Rev 2013 Sep 30;9:CD001116. doi: 10.1002/14651858.CD001116.pub4.
208. Bernstein D. American college of Allergy Asthma and Immunology. 2014
209. Beggs S, Foong YC, Le HC, Noor D, Wood-Baker R, Walters JA. Swimming training for asthma in children and adolescents aged 18 years and under. Cochrane Database Syst Rev 2013 Apr 30;4:CD009607. doi: 10.1002/14651858.CD009607.pub2
210. Grande AJ, Silva V, Andriolo BNG, et al. Is water-based exercise an effective and safe type of exercise for adults. Cochrane Database of Systematic Reviews 2014
211. Lopes EA, Fanelli-Galvani A, Prisco CC, et al. Assessment of muscle shortening and static posture in children with persistent asthma. Europ J Pediatr 2006;166(7):715-721
212. Goldthwait JE, Brown LT, Swaim LT, Kuhns JG. The chest. In: Essentials of body mechanics in health and disease. Philadelphia: JB Lippencott Co. 1952:53-64
213. Kuznetsov NA, Luberto CM, Availone K, et al. Characteristics of postural control among young adults with asthma. J Asthma 2015;52(2):191-197
214. Chebbo A, Tfaili A, Jones SF. Hypoventilation syndromes. Med Clin North Am 2011;95(6):1189-1202
215. Kangilaski J. Chiropractic can involve more than spinal manipulation. Forum on Med 1978;Nov:33-35
216. Krogulska A, Dynowski J, Wasowska-Krolikowska K. Bronchial reactivity in schoolchildren allergic to food. Ann Allergy Asthma Immunol 2010 Jul;105(1):32-8.
217. Kaliner M, Shelhamen JH, Davis PB, Smith L J Venter JC Autonomic nervous system abnormalities and allergy. Annals of Internal Medicine 1982;96:349-357
218. Li TC. Can foods affect my asthma symptoms? 2017. Mayo Clinic.
219. Ferreira IM, Brooks D, White J, Goldstein R. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012;Decd 12;12:CD0000998. doi: 10.1002/14651858.CD000998.pub3
220. Smoking and asthma. Australian Asthma Handbook. 2017.
221. Brozovich TA. The reduction of asthma symptoms and medication after chiropractic care. Chiropr J Aust 2017;45:138-143
222. Lord E. Patients with asthma turning to CAMS. Aust Doctor 6 Sept. 2013.
223. Fact Sheet. Asthma and complementary therapies and Complimentary Therapies Feb2013.pdf.aspx. May 2012
224. Schneider A, Ginner L, Tilemann L, et al. Diagnostic accuracy of spirometry in primary care. BMC Pulmonary Medicine 2009, 9:31 doi:10.1186/1471-2466-9-31
225. Eastwood HL. Complementary therapies: the appeal to general practitioners. Med J Aust 2000;173:95-98
226. Dovey D. 10 Medical breakthroughs and life-saving drugs discovered by accident, from pap smears to laughing gas.
227. Redwood D, Cleveland CS. Fundamentals of chiropractic. St Louis. Mosby.2003;355,360,536-539
228. Walker S, Cramb S. Diagnosis and management of asthma in children. BMJ 2015;350:h996